The research work was carried out to investigate the combination effect of dexamethasone with glipizide for a period of two weeks on blood glucose and triglyceride levels in wistar rats by oral route. Healthy young adult wistar rats of six to eight weeks old were randomly divided in to five groups. Out of five groups (6 rats/sex/group), one group was kept as control received vehicle alone and other three groups were treated with dexamethasone alone at different dose levels (2.5, 6.25 and 12.5 mg/kg) and another one group of rats received a combination of dexamethasone and glipizide at 12.5 and 2.0 mg/kg, respectively. At the end of treatment period, blood sample was collected from each animal for the estimation of glucose and triglyceride levels. A significant (p<0.01) increase in blood glucose and triglyceride level was noticed on 15th day following administration of dexamethasone at all dose levels in both the sexes. On the other hand, animals treated with combination of dexamethasone and glipizide showed significant (p<0.01, p<0.001) decrease in blood glucose and triglyceride levels in both male and female rats at the end of study period. This effect of combination therapy reveals an ameliorative effect of glipizide on dexamethasone induced hyperglycemia and increased triglyceride level in the blood. Based on the findings, it may be concluded that oral administration of glipizide along with dexamethasone has an ameliorative effect on blood glucose and triglyceride levels in rats indicate this combination therapy may be explored further in the treatment of diabetic arthropathy.
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